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Sodium Difluoride Sodium Difluoride is toxic. Ingested, a lethal dose of fluoride for a 70 kg human could be around 5 to 10 g[1]; however, the minimum lethal dose is approximately 5 mg per 1 kg in body weight[4], which is 350 mg (0.35 g) fluoride for a 70 kg human. Even so, acute toxicity can occur in much lower doses.[5] A tube of toothpaste may generally contain anywhere from 1000 ppm to 5000 ppm (1000 mg to 5000 mg) of sodium fluoride
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